吴秀稳博士简介
发布时间:2019-12-09 浏览次数:0次
吴秀稳,女,博士,毕业于北京大学,2018年入职6163银河.net163.am。博士期间研究方向为“中药羌活的化学成分及体内过程”,通过研究获得了一系列活性香豆素和酚酸酯,提出了除异欧前胡素、羌活醇外,紫花前胡苷、佛手柑素和苯乙基阿魏酸酯可作为羌活质量控制的定量指标,发现了羌活化学成分吸收与结构关系的规律,推测了与P-gp结合的3类活性结构,揭示了羌活化学成分在大鼠体内的动态变化规律,为阐明羌活药效物质基础、提高质控水平和以香豆素和酚酸酯为中心的新药研究与开发提供了科学依据。已发表SCI论文12篇,其中第一作者4篇。
目前科研方向为:(1)中药化学成分的抗炎作用机制;(2)中药化学成分与药物转运体的相互作用。主持河北省自然科学基金1项,河北省教育厅基金1项和6163银河.net163.am春雨计划启动基金1项。
发表论文:
1. Xiu-WenWu, You-Bo Zhang, Lei Zhang, Xiu-Wei Yang*. Simultaneous quantification of 33 active components in Notopterygii Rhizoma et Radix using ultra high performance liquid chromatography with tandem mass spectrometry, Journal of Chromatography B, 2018, 1092: 244?C251.(IF=2.813)
2. Xiu-WenWu, Wei Wei, Xiu-Wei Yang*, You-Bo Zhang, Wei Xu, Yan-Fang Yang, Guo-Yue Zhong, Hong-Ning Liu, Shi-Lin Yang. Anti-inflammatory phenolic acid esters from the roots and rhizomes of Notopterygium incisium and their permeability in the human Caco-2 monolayer cell model, Molecules, 2017, 22(6): 935?C944. (IF=3.060)
3. Xiu-Wen Wu, Ru-Feng Wang*, Li-Jia Liu, Li-Na Guo, Can Zhao. Absorbability, mechanism and structure-property relationship of three phenolic acids from the flowers of Trollius chinensis, Molecules, 2014, 19(11): 18129?C18138. (IF=3.060)
4. Xiu-Wen Wu, Ru-Feng Wang*, Ming Yuan, Wei Xu, Xiu-Wei Yang. Dulbecco's modified eagle's medium and minimum essential medium?Cwhich one is more preferred for establishment of Caco-2 cell monolayer model used in evaluation of drug absorption? Pharmazie, 2013, 68(10): 805?C810.(IF=2.145)
5. Wei Wei, Xiu-WenWu, Xiu-Wei Yang*. Novel phthalide derivatives from the rhizomes of Ligusticum chuanxiong and their inhibitory effect against lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophage cells, RSC Advances, 2017, 19(7): 704?C711.(IF=3.049)
6. Wei Wei, Xiu-WenWu, Gai-Gai Deng, Xiu-Wei Yang*. Anti-inflammatory coumarins with short- and long-chain hydrophobic groups from roots of Angelica dahurica cv. Hangbaizhi, Phytochemistry, 2016, 19(7): 704?C711.(IF=2.905)
7. Li-Jia Liu, Xiu-Wen Wu, Ru-Feng Wang*, Yu-Shuai Peng, Xin Yang, Jun-Xiu Liu. Guo Absorption properties and mechanism of trolline and veratric acid and their implication to an evaluation of the effective components of the flowers of Trollius chinensis, Chinese Journal of Natural Medicines. 2014, 12(9): 700?C704.(IF=1.773)
8. Ru-Feng Wang*, Xiu-Wen Wu, Li-Jia Liu, Yan-Nan An. Activity directed investigation on anti-inflammatory fractions and compounds from flowers of Trollius chinensis, Pakistan journal of pharmaceutical sciences, 2014, 12(9): 285?C288.(IF=0.596).
9. Ru-Feng Wang*, Xiu-Wen Wu, Di Geng. Two cerebrosides isolated from the seeds of Sterculia lychnophora and their neuroprotective effect, Molecules, 2013, 27(2): 1181?C1187.(IF=3.060).